More on NonTubercle Mycobacteria

Below is a number of links and some text  about None-Tubercle Bacteriam, NTM, and especially Mycobacterium Avium Complex (MAC), .. and more ” ..infections start slow and gradually get worse over time .. Symptoms of disseminated mycobacterium avium complex infections can include symptoms: Fever, Sweating, Fatigue, Weight Loss, Diarrhea, Shortness of breath, Abdominal pain, Anemia … ”.. and NTM may also present as localized disease involving extrapulmonary sites such as lymph nodes, skin and soft tissues and rarely bones. .. Rapid molecular tests are now available for confirmation of NTM diagnosis at species and subspecies level. Drug susceptibility testing (DST) is not routinely done except in non-responsive disease due to slowly growing mycobacteria (M. avium complex, M. kansasii) or infection due to rapidly growing mycobacteria, especially M. abscessus. While the decision to treat the patients with NTM-PD is made carefully, the treatment is given for 12 months after sputum culture conversion. Additional measures include pulmonary rehabilitation and correction of malnutrition. Treatment response in NTM-PD is variable and depends on isolated NTM species and severity of the underlying PD. Surgery is reserved for patients with localized disease with good pulmonary functions. Future research should focus on the development and validation of non-culture-based rapid diagnostic tests for early diagnosis and discovery of newer drugs with greater efficacy and lesser toxicity than the available ones.”

To avoid misunderstanding an answer on the question: ”What is the difference between mycotoxins and Bacterial mycotoxins?” “Mycotoxins are produced by fungi as secondary metabolites, while bacterial toxins are produced by bacteria to target host cells. Unlike many bacterial toxins which are proteins, mycotoxins are haptens of low molecular weight that need to be conjugated to a protein before they can be recognized by antibodies”.

More is coming