2026-05-22 The very below a very new, and functioning (perhaps)revolutionary hypotes
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Until text is coming below, quite much text is to be found at Placebo R&D | Biopsychosocial Medicine
Axiom 1: Hypnosis refers to Limbic information/elaboration processing – internal and external spatial communication, if which we have limited understanding of, especially how we optimize individuals to use spatial AND verbal in internal dialogue – thus, some we can assume/guess. When mixing spatial and verbal thinking some of it is understood and to some extent subjected to consciousness awareness.
Axiom 2a: The placebo and nocebo effect is also limited understood but is assumed to refer to also Limbic/spatial processing but probably not direct conscious rational identified/observed/ …
Axiom 2b: We also assume that placebo and nocebo to degree from 0 to completely interacting/interplaying, which is an important notion while if only psychological there will not be any substantial changes/influences on biological/physiological dysfunctions (have quite clear case examples, e.g. on patient felt well and said I can make it, I am sure, which psychological data ”refused to confirm”) while psychophysiological placebo/nocebo can make a difference, which we have problem with to measure effectively – but can assume when substantial changes occurs as probably in The 1957 Placebo case – the Krebozen story | Biopsychosocial Medicine
Axiom 3: We can also with own self-care toolboxes, where individuals during workshops learn to tailoring their tools and thereby increase effects of placebo, that is, the use of the tools by themselves but also specific placebo strategies.
Axiom 4: We easily forget the possibility of dynamic interactions between placebo and nocebo processes – of course while we cannot in real clearly measure ”what up”, BUT, we can practically try to identify nocebo-like attitudes and try to (separately?) reciprok them.
Below I will discuss some specific strategy prototypes based on the above Axioms.
2026-05-22
NB early placebo-nocebo measurable hypothesis
See the dynamic picture on placebo-nocebo and image this is a consequence of united mental focuses integrating both verbal (last 300.000 years evolution AND Limbic system´s spatial part connected with evolutionary hierarchical biological systems since at least mammalian “evolution start” based on at least aa few billion of years evolution where the symbiosis of primitive cell and a penetrating bacteria, which is the “mother” of mitochondria! Until
Image also that this interplay, not consciously clearly understood and observed consciously IS what we call a dynamic placebo-nocebo process, which means that our basic integrated view of ongoing processes is influenced by such dynamic process.
Can this be measured? Yes, perhaps. Next, think about our focus on autonomic systems general and specific importance for our health/unhealth development but our non-focus and the (perhaps) equal importance of neurotransmitters (more) complex processes and its importance for health/unhealth development! What. If the above over ride ANS or a synergistic increase the positive (placebo) or negative (nocebo) interplay with the goings-on, then this can be measured dynamic with ANS measures or more complex, but possible, with signal substances, where e.g. GABA is critical. Experimental we can investigate this measuring GABA in urine, while changes in GABA would be possibly a priori predicted and … found out how the NT changes.
If the about would be clearly validated, then we need to restart measuring of catecholamines but also add other NT as Glutamate and GABA … ND, er have much to learn while present clinical knowledge is extremely low!
IF, the above is possible, then we could also via quantum based psychophysiological behavioral medicine and a kind of biofeedback influence this dynamic effect, which then is not only subjective imaged but psychophysiological working as a part of different kind of other self-care tools and health care strategies.