Possible explanation why healthy tissue becomes harder (sclerosis)

Below are links to process associated with the heading . The starting point is to find out if what (crucial for the development of all life) started about 3 billion years ago lays the foundation for the development of calluses/sclerosis of healthy tissue, partly theoretically and partly (further) develop clinical practical methods to prevent and cure all types of sclerosis given hypothetical common denominators can be confirmed. Most often, MS is mostly discussed, but there are (as we know) several diagnostic variants such as systemic sclerosis, ALS … But perhaps also diagnoses that do not contain the word sclerosis because we have not realized that this process development, perhaps indirectly, constitutes a prerequisite, e.g. because micro-dysfunctions in energy processes also have (perhaps unforeseen) critical consequences.

My more detailed clinical hypotheses are not included in the below but links from others who in various ways are engaged in the initial gross hypothesis – many catalysis micro dysfunctions directly and/or indirectly affect the development of ill health of different complexity and severity. We do not work with absolute knowledge and therefore we should humbly also dare to try to process even what today looks impossibly difficult where the knowledge is extremely insufficient!

”Healthy tissue becomes hard (sclerosis) due to the body mistakenly producing excessive collagen (fibrosis), often triggered by immune system overactivity (autoimmunity), leading to scarring and stiffness, seen in conditions like scleroderma (collagen buildup) or Multiple Sclerosis (scarring in CNS), where chronic inflammation and repair processes go awry, disrupting normal function. It’s a complex interplay of immune dysfunction, genetics, and environmental factors causing fibroblasts to overproduce collagen or the immune system to damage protective layers like myelin, resulting in hardened, fibrotic tissue.

Key Explanations for Sclerosis

  1. Autoimmune Attack & Fibrosis (e.g., Scleroderma)

Immune System Misdirection: The immune system mistakenly attacks healthy connective tissues, signaling cells (fibroblasts) to produce too much collagen.

Excess Collagen Buildup: This leads to a fibrotic, scar-like tissue (sclerosis) that thickens and stiffens the skin and organs, impairing their function.

Vascular Damage: Blood vessel injury also triggers this process, creating a cycle of inflammation and scarring.

  1. Immune-Mediated Demyelination (e.g., Multiple Sclerosis – MS)

Myelin Attack: In MS, the immune system targets myelin, the protective sheath around nerve fibers in the central nervous system (CNS).

Scarring (Sclerosis): The body tries to repair the damaged myelin, but scar tissue (sclerosis) forms instead, disrupting nerve signals between the brain and body.

  1. Chronic Inflammation & Repair Dysregulation

Persistent Damage: Repeated inflammation, from whatever cause (infection, autoimmune response), leads to continuous attempts at tissue repair.

Abnormal Repair: Instead of returning to normal, these repair processes result in excessive deposition of fibrous connective tissue (collagen, glial cells), causing hardening and loss of normal tissue structure.

  1. Genetic & Environmental Triggers

Genetic Predisposition: Certain genes can make individuals more susceptible to autoimmune responses or related conditions.

Environmental Factors: Viruses (like EBV in MS), drugs, obesity, and low Vitamin D levels are being investigated as potential triggers that initiate or worsen these sclerotic processes.

In essence, sclerosis happens when the body’s defense or repair mechanisms overreact to perceived threats (or actual damage), leading to a buildup of tough, fibrous material where soft, functional tissue should be” https://www.google.com/search?q=Different+explanations+for+why+healthy+tissue+becomes+harder+(sclerosis)&oq=Different+explanations+for+why+healthy+tissue+becomes+harder+(sclerosis)&gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCTQzNjNqMGoxNagCCLACAQ&sourceid=chrome&ie=UTF-8

      Quantum role why healthy tissue becomes harder (sclerosis)

  1. Rethinking Disease: How the Quantum Biology of Ferritin Could Change the Game | by Chris Rourk
    https://www.boaim2.se/qm/quantum-medicine-2024/neurodegenerative-diseases-arise-from-oxidative-damage-to-electron-tunneling-proteins-in-mitochondria/rethinking-disease-how-the-quantum-biology-of-ferritin-could-change-the-game-by-chris-rourk/
    What do cancer, multiple sclerosis, atrial fibrillation, macular degeneration and Parkinson’s disease possibly have in common? See more the link above ….
  2. How can we clinically using quantum biology/medicine for prevent and recovering different kind of sclerosis processes in human bod
    Clinically using quantum biology for sclerosis involves advanced biophysics like laser/plasma therapies, nanotechnology for drug delivery (e.g., targeting lesions), and novel compounds (like Quantum BioPharma’s Lucid-MS) promoting myelin repair, aiming to reduce inflammation, stimulate remyelination (OPC differentiation), and modulate immune responses, though many approaches are still experimental or in trials. Key strategies focus on boosting natural repair, regulating immunity, and delivering therapies across the blood-brain barrier, with techniques like Photobiomodulation (PBM) showing promise in reducing inflammation and improving function.

Quantum-Inspired Approaches & Technologies

Laser & Plasma Therapy: Uses directed energy/fields (like proton plasma) for targeted cellular effects, reducing inflammation and symptoms in MS, complementing traditional rehab.

Photobiomodulation (PBM): Low-level light therapy, a quantum-influenced method, shows promise in increasing anti-inflammatory factors (IL-10), improving motor function, and stimulating oligodendrocyte precursors (myelin-makers) in animal models, with clinical trials ongoing for MS.

Nanotechnology: Using nanoparticles (e.g., magnetic, liposomal) to deliver drugs across the blood-brain barrier directly to sclerotic lesions, enhancing treatment efficacy.

Molecular & Cellular Strategies

Remyelination Drugs: Targeting M1R receptors (like with PIPE-307) or using novel compounds (K102, K110) to trigger oligodendrocyte maturation and myelin sheath regeneration, a major focus for repair.

Immune Modulation: Developing copolymers (like Glatiramer Acetate) to shift immune responses from destructive to anti-inflammatory (Th2) and generate regulatory T cells.

Stem Cell Therapy: Autologous hematopoietic stem cell transplantation (AHSCT) aims for long-term disease stabilization by resetting the immune system, used in aggressive cases.

Potential ”Quantum” Healing Mechanisms

Cellular Coherence: Exposure to natural light/reducing blue light may support cellular communication and mitochondrial function, aiding recovery.

Quantum Tunneling: In healing, particles might bypass energy barriers faster, speeding up enzymatic repair, though this is more a fundamental biological concept than a direct clinical application yet.

Current Clinical Status

Many quantum/biophysical methods (PBM, plasma) are promising but often used adjunctively or in trials.

Companies like Quantum BioPharma are advancing specific compounds (Lucid-MS) into clinical trials for myelin repair.

The field is moving towards personalized, multi-targeted therapies that combine immune control with myelin repair. https://www.google.com/search?q=2.+How+can+we+clinically+using+quantum+biology%2Fmedicine+for+prevent+and+recovering+different+kind+of+sclerosis+processes+in+human+body&oq=2.%09How+can+we+clinically+using+quantum+biology%2Fmedicine+for+prevent+and+recovering+different+kind+of+sclerosis+processes+in+human+body+&gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCzE4ODQ1NWowajE1qAIIsAIB&sourceid=chrome&ie=UTF-8

 

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis
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Fig 1. Main targets to achieve neuroprotection in multiple sclerosis. Drugs under development to achieve a neuroprotective effect have different mechanisms of actions including the promotion of (1) axonal functioning, (2) glial regulation, (3) the integrity of the blood–brain–barrier myelin integrity, and (4) recovery of myelin-protective functions
https://link.springer.com/article/10.1007/s40120-022-00363-7

  1. Can extreme micro small dysfunction in catalysts/enzymes via microconidia be associated with development of sclerosis?

https://www.google.com/search?q=Can+extreme+micro+small+dysfunction+in+catalysts%2Fenzymes+via+microchondia+be+associated+with+development+of+sclerosis%3F&oq=Can+extreme+micro+small+dysfunction+in+catalysts%2Fenzymes+via+microchondia+be+associated+with+development+of+sclerosis%3F+&gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCzE5MzQxNGowajE1qAIIsAIB&sourceid=chrome&ie=UTF-8

Yes, there’s strong evidence linking mitochondrial dysfunction, including issues with enzymes (catalysts) within them, to multiple sclerosis (MS), contributing to energy failure, oxidative stress, inflammation, and nerve damage (demyelination, axonal loss). Mitochondria are crucial for neuron survival, and their impairment leads to energy imbalance, ROS production, and ultimately neurodegeneration seen in MS, making them a significant factor in the disease’s development and progression.

How Mitochondrial Dysfunction Contributes to Sclerosis:

Energy Crisis: Mitochondria produce ATP (energy); dysfunction leads to energy deficits, especially harmful to energy-demanding neurons, causing nerve damage.

Oxidative Stress: Impaired mitochondria generate excessive Reactive Oxygen Species (ROS), damaging cells and myelin.

Enzyme & Gene Issues: Studies show reduced activity of mitochondrial enzymes (like those in the respiratory chain) and DNA defects in MS patients.

Inflammation & Cell Death: Mitochondrial problems trigger inflammation (neuroinflammation) and apoptosis (programmed cell death), worsening MS pathology.

Specific Examples: Reduced enzyme activity (e.g., succinate dehydrogenase) and abnormalities in mitochondrial networks are observed in MS tissues.

Key Takeaway:

Mitochondrial dysfunction isn’t just a symptom; it’s deeply involved in MS pathogenesis, affecting neurons and the immune response, and is considered a core factor in the disease’s relentless progression
https://www.google.com/search?q=Can+extreme+micro+small+dysfunction+in+catalysts%2Fenzymes+via+microchondia+be+associated+with+development+of+sclerosis%3F&oq=Can+extreme+micro+small+dysfunction+in+catalysts%2Fenzymes+via+microchondia+be+associated+with+development+of+sclerosis%3F+&gs_lcrp=EgZjaHJvbWUyBggAEEUYOdIBCzE5MzQxNGowajE1qAIIsAIB&sourceid=chrome&ie=UTF-8

Quantum Tunneling of Protons through Respiratory

Complex I of Mitochondria

https://biointerfaceresearch.com/wp-content/uploads/2025/08/BRIAC154.059.pdf

Abstract: Mitochondria are the major cellular organelles responsible for ATP production. They produce ATP through the process of oxidative phosphorylation, in which the proton motive force (pmf) is the driving force by which protons pass through ATPase. The pmf is generated by the pumping activity of the electron transport chain ETC, particularly complexes I, III, and IV. As the proton can be physically described as a quantum wave, it is important to explore the role of the quantum behavior in its transport through the ETC proteins, particularly the respiratory complex I. In the present study, the potential functions of three subunits of complex I were identified, and the Schrödinger equation was solved numerically by the finite difference method using MATLAB to obtain the eigenstates and their corresponding eigenvalues. In addition, quantum tunneling probability and quantum conductance values were calculated using WKB approximation for the eigenenergies of the proton in each potential barrier. Moreover, entropic tunneling delay time and tunneling currents were calculated. Our results indicate that quantum tunneling transport yields significant values of quantum conductance that can contribute significantly to the pmf while utilizing less than 45 % of the required energy to overcome the barriers of the subunits in respiratory complex I.

Mitochondrial respiration, also known as aerobic cellular respiration, is a multi-step process that converts the chemical energy in glucose and other food molecules into ATP, largely occurring within the mitochondria. https://www.bing.com/search?q=mitochondria%20respirattion&qs=n&form=QBRE&sp=-1&ghc=1&lq=0&pq=mitochondria%20respirattion&sc=1-25&sk=&cvid=D69F6D628AD6444FA7B3AEDF35BB613B

How are Photosynthesis and Cellular Respiration Relate

Photosynthesis is a process by which green plants and algae make food in the form of carbohydrates (C6H12O6) using water (H2O), carbon dioxide (CO2), and chlorophyll in the presence of sunlight as the energy source. Water and oxygen are produced as byproducts. In contrast, cellular respiration breaks down carbohydrates produced through photosynthesis and uses oxygen to produce energy and carbon dioxide. The carbon dioxide is again utilized during photosynthesis to continue the cycle.

The relationship between photosynthesis and cellular respiration can be best understood using the chemical equations given below: …..
https://www.sciencefacts.net/photosynthesis-and-cellular-respiration.html

Reverse processes
Photosynthesis and cellular respiration are considered reverse processes because they involve the
same molecules but in opposite directions. Photosynthesis uses carbon dioxide and water to produc
glucose and oxygen, storing energy from sunlight in the chemical bonds of glucose.

https://www.bing.com/search?pglt=297&q=Respiration+Photosyntes+backwards&cvid=fb345f7b88c141a69956163716f1ad36&gs_lcrp=EgRlZGdlKgYIABBFGDkyBggAEEUYOdIBCTE2ODIwajBqMagCALACAA&FORM=ANNTA1&PC=SCOOBE

 

      Caution BUT the below link contains very thoughtful and practical application to integrate……..

Are You Blocking Your Own Healing? Quantum Biology Explains Why
https://www.lukecoutinho.com/blogs/emotional-wellness/healing-faster-through-quantum-biology/
…. Could the missing link be Quantum Biology? The human body isn’t just a collection of cells, organs, and tissues—it is energy. Every thought, every emotion, every environment we expose ourselves to impacts us at a subatomic level. Quantum biology is a field of science that explores how these microscopic, energetic interactions influence health, disease, and recovery.

 

What if healing isn’t just about medicine and nutrition, but also about restoring balance within our body’s energy field?

What if true recovery lies not just in suppressing symptoms, but in aligning with the body’s natural intelligence and working with it, not against it?

Let’s explore this.

The Science of Quantum Biology: How Healing Happens Beyond the Physical

For the longest time, medicine has been rooted in biochemistry—we analyze blood work, hormones, inflammatory markers, and cellular health to diagnose and treat diseases. And while this approach has saved lives, science is now showing us that healing isn’t just about chemicals, nutrients, or even lifestyle changes. There’s a deeper layer to it—an energetic layer.

This is where Quantum Biology comes in. It is a study of how the laws of quantum physics—the science that governs subatomic particles, apply to human biology and healing.

Just like our brain uses electrical signals to communicate, our cells also exchange light and energy to function efficiently. Healing is not just about what we eat, how we move, or the medications we take—it is also about how our cells vibrate, communicate, and transfer energy.

Let’s break it down into three key principles of quantum biology that can radically transform how we look at healing.

  1. Quantum Coherence: The Silent Language of Cells

Cells don’t just communicate through chemical signals—they emit and respond to light. This concept, known as biophoton emission, was discovered by German physicist Fritz-Albert Popp in the 1970s. His research showed that living cells store and release light to regulate biological functions.

Are You Blocking Your Own Healing? Quantum Biology Explains Why

Source: Sanders C. L. (2014). Speculations about Bystander and Biophotons. Dose-response : a publication of International Hormesis Society, 12(4), 515–517. https://doi.org/10.2203/dose-response.14-002.Sanders

Think of your body as an orchestra. Every cell is an instrument that must be in sync for the body to function optimally. But when disease sets in, whether it’s cancer, autoimmunity, or chronic pain, this harmony is disrupted. The light communication between cells becomes chaotic. This is why people with chronic illnesses often feel disconnected, exhausted, and inflamed—their body’s energy is literally out of tune.

Ever wondered why sunlight makes you feel energized?

It’s not just about vitamin D. Sunlight helps regulate these biophotons, restoring the body’s quantum coherence and enabling better cellular communication.

Research published in PloS one shows that morning sunlight exposure enhances mitochondrial function, reduces inflammation, and improves mood.

Are You Blocking Your Own Healing? Quantum Biology Explains Why

Source: Shinhmar, H., Hogg, C., & Jeffery, G. (2023). Exposure to long wavelength light that improves aged mitochondrial function shifts acute cytokine expression in serum and the retina. PloS one, 18(7), e0284172. https://doi.org/10.1371/journal.pone.0284172

How to Restore Cellular Coherence:

Step into natural sunlight for at least 10–15 minutes daily to regulate your body’s quantum coherence.

Reduce blue light exposure at night, as artificial light disrupts cellular communication and melatonin production, leading to poor recovery.

Are You Blocking Your Own Healing? Quantum Biology Explains Why

Image Credits: Freepik

  1. Quantum Tunneling: How Your Body Defies Physical Barriers to Heal Faster

In classical biology, we are taught that chemical reactions happen in a step-by-step manner—like a slow-moving train stopping at multiple stations before reaching its destination. But in reality, healing doesn’t always follow such predictable patterns.

 

Quantum tunneling allows particles to bypass barriers instantly, speeding up essential processes like enzymatic reactions, DNA repair, and energy production in mitochondria.

 

For example, when you cut your skin, enzymes rush to repair the damage. Traditional biology would say they move through physical pathways, but quantum tunneling allows them to ‘jump’ across energy barriers, accelerating wound healing. This also explains why some people recover faster than others—their body’s ability to utilize quantum effects is stronger.

Are You Blocking Your Own Healing? Quantum Biology Explains Why

Source: Matarèse, B. F. E., Rusin, A., Seymour, C., & Mothersill, C. (2023). Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model. International journal of molecular sciences, 24(22), 16464. https://doi.org/10.3390/ijms242216464

What should you do?

Support enzymatic efficiency by including electron-dense foods like raw honey, and dark leafy greens. These boost antioxidant activity and quantum tunneling.

Optimize mitochondrial function with grounding (walking barefoot on earth)—this enhances the body’s ability to transfer electrons efficiently. Grounding (earthing) reconnects the body to the Earth’s natural frequencies, reducing inflammation and improving energy flow. Breathwork optimizes oxygen levels, creating the right conditions for cellular healing.